Research note

Perineuronal Net Modulation in Early-Life Stress Models

Context

Focused on how maternal deprivation impacts ECM structures and developmental trajectories in young adult rat brains.

Raw image and processed view

A simple comparison of microscopy signal and processed segmentation output.

Raw microscopy image
Processed microscopy image

Annotated image

Highlighted points connect image regions to interpretation notes.

Microscopy annotation layer

Closer view

A closer look at the processed microscopy image.

Zoomable processed microscopy image

Process

1. Preprocessing

Noise control and intensity normalization across sample sets.

2. Segmentation

Per-region segmentation to track perineuronal structures.

3. Quantification

Signal density and distribution analysis in SPSS and Python.

4. Interpretation

Integrated imaging findings with developmental stress literature.